Key result
The angiotensin AT1-receptor blockers KT3-671 and losartan significantly and dose-dependently potentiated bradycardia induced by vagal nerve stimulation in pithed rats.
Population
Male Wistar rats (300-450 g), pithed rat preparation
Comparison
Angiotensin AT1-receptor blockers administered… vs Saline control
Design
Preclinical
Authors
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May explain absent reflex tachycardia with ARBs in rats; leaves open clinical relevance and requires human studies.
p-value: p=<0.05
AT1-receptor blockers enhance cardiac vagal neurotransmission by blocking the inhibitory effect of endogenous AngII on presynaptic AT1 receptors, which may explain the lack of reflex tachycardia following ARB-induced hypotension.
Yamaki et al. (2013) studied Healthy (Animal Model). KT3-671 and losartan vs. Saline was evaluated on Bradycardia induced by vagal nerve stimulation (VNS) (p=<0.05). The angiotensin AT1-receptor blockers KT3-671 and losartan significantly and dose-dependently potentiated bradycardia induced by vagal nerve stimulation in pithed rats.
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