Key result
KT3-671 dose-dependently inhibited the pressor response to sympathetic stimulation in pithed rats, being approximately 4 times more potent than losartan, without affecting cardiac responses.
Population
Pithed rats (with and without adrenals)
Comparison
KT3-671 (1-10 mg/kg, i.v.) vs Losartan (1-10 mg/kg, i.v.)
Design
Preclinical
Authors
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Hypothesis-generating for vascular-selective sympathoinhibition; leaves open clinical translation of KT3-671.
KT3-671 inhibits vascular but not cardiac sympathetic neurotransmission in pithed rats, contributing to its antihypertensive efficacy.
Takata et al. (2001) studied this question. KT3-671 vs. losartan was evaluated on pressor response to sympathetic stimulation. KT3-671 dose-dependently inhibited the pressor response to sympathetic stimulation in pithed rats, being approximately 4 times more potent than losartan, without affecting cardiac responses.
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