Why the study?
Does acebutolol reduce blood pressure in diabetic patients with mild to moderate hypertension?
Does acebutolol reduce blood pressure in diabetic patients with mild to moderate hypertension?
Acebutolol effectively lowers blood pressure in diabetic patients with mild to moderate hypertension without adversely affecting glycemic control or causing significant side effects.
Supports acebutolol for mild-moderate hypertension in diabetics; confirms glycemic safety in RCT evidence.
A double-blind, parallel group comparison study was carried out in 20 diabetic patients with mild to moderate hypertension to assess the effectiveness and tolerance of acebutolol compared with placebo. After a 4-week wash-out period on placebo, patients received either 400 mg acebutolol or placebo once daily for 12 weeks and then placebo for a further 4 weeks. The results showed that acebutolol was more effective than placebo in lowering raised blood pressure in these patients. No deterioration in diabetic control occurred during the study and no significant side-effects of the drug were observed compared with placebo. In particular, the previously described side-effects of beta-blocker therapy in diabetic patients were not observed as a clinical problem in this study.
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Fraser et al. (1986) studied this question.
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