What does this research mean for the field?

Acebutolol significantly reduces blood pressure in hypertensive patients, maintains control with once-daily dosing over 24 hours, and its blood pressure-lowering effect correlates with changes in plasma renin activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1978British Journal of Clinical PharmacologyOpen Access

Acebutolol in hypertension‐double‐blind trial against placebo.

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Why the study?

Does acebutolol reduce blood pressure and pulse rate in hypertensive patients?

Population

11 hypertensive patients

Comparison

Acebutolol 200-600 mg twice daily or once daily vs Placebo

Design

RCT, double-blind

Authors

MMM A MartinHospital Universitario Ramón y Cajal CPC. PhillipsRoslin Institute ASA. J. SmithSignature Healthcare Brockton Hospital

Discussion

Member takes

Implication

Supports acebutolol for hypertension; confirms beta-blocker efficacy across postural and exertional states.

Structured PICO

Does acebutolol reduce blood pressure and pulse rate in hypertensive patients?

Population

11 hypertensive patients

Intervention

Acebutolol 200-600 mg twice daily or once daily

Comparator

Placebo

Outcome

Blood pressure and pulse rate (lying, standing, and after exercise)surrogate

Acebutolol significantly reduces blood pressure and pulse rate in hypertensive patients, with efficacy maintained on a once-daily dosing regimen.

Cite This Study

Martin et al. (1978) studied this question.

synapsesocial.com/papers/6a12e6ec5bb7edc7189e71b0 https://doi.org/10.1111/j.1365-2125.1978.tb00863.x

Topics

Hypertension management Echocardiography

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Bookmark

Acebutolol in hypertension‐double‐blind trial against placebo.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Acebutolol in hypertension‐double‐blind trial against placebo.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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