Why the study?
Does acebutolol 400 mg once daily reduce blood pressure similarly to acebutolol 200 mg twice daily in hypertensive patients?
Population
13 hypertensive patients
Comparison
Acebutolol 400 mg once daily administered for 4… vs Acebutolol 200 mg twice daily and placebo…
Design
RCT, random order, double-blind
Follow-up
4 weeks per treatment period
Authors
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Supports once-daily acebutolol dosing in hypertension; confirms equivalent 24-h BP reduction to twice-daily regimen.
Does acebutolol 400 mg once daily reduce blood pressure similarly to acebutolol 200 mg twice daily in hypertensive patients?
Acebutolol 400 mg once daily provides similar blood pressure control to 200 mg twice daily, supporting the convenience of once-daily dosing in hypertension.
Watson et al. (1980) studied this question.
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