Key result
Acebutolol and metoprolol showed no significant difference in reducing blood pressure, but metoprolol reduced resting heart rate to a significantly greater degree (p<0.05).
Why the study?
Does acebutolol compared to metoprolol improve blood pressure and heart rate in patients with hypertension?
RCT (n=28)
Double-blind
Crossover
Does acebutolol compared to metoprolol improve blood pressure and heart rate in patients with hypertension?
p-value: p=<0.05
Acebutolol and metoprolol provide similar antihypertensive efficacy, but metoprolol causes a greater reduction in resting heart rate.
No takes yet. Share an insight, caveat, or question.
Either beta-blocker may suit hypertension; confirms comparable efficacy while informing heart rate-based selection in trials.
Mänttäri et al. (1982) conducted an RCT in Hypertension (n=28). Acebutolol vs. Metoprolol 200 to 400 mg daily was evaluated on Systolic and diastolic blood pressure and heart rate (sitting, lying, post-exercise) (p=<0.05). Acebutolol and metoprolol showed no significant difference in reducing blood pressure, but metoprolol reduced resting heart rate to a significantly greater degree (p<0.05).
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