Why the study?
Does PEG-SOD reduce infarct size in a canine model of myocardial ischemia/reperfusion injury?
Population
44 dogs subjected to occlusion of the circumflex coronary artery for 90 minutes followed by reperfusion.
Comparison
Superoxide dismutase conjugated to polyethylene… vs Polyethylene glycol conjugated to albumin.
Design
Preclinical
Follow-up
6 hours or 4 days
Authors
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PEG-SOD reduced infarct size in canine ischemia/reperfusion; extends antioxidant data but leaves open human translation.
Does PEG-SOD reduce infarct size in a canine model of myocardial ischemia/reperfusion injury?
PEG-SOD provides sustained protection against myocardial ischemia/reperfusion injury, significantly reducing infarct size in a canine model.
Tamura et al. (1988) studied this question.
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