Analgesic Nephropathy

Editorials1 April 1968Analgesic NephropathyPRISCILLA KINCAID-SMITH, M.B., F.R.A.C.P., D.C.P.PRISCILLA KINCAID-SMITH, M.B., F.R.A.C.P., D.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-4-949 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough 15 years have passed since this topic was first introduced (1), the controversy about the effect of analgesics on the kidney continues. Opposite views were expressed at a meeting devoted to this subject 10 years ago (2), and in spite of active research since then, many of the major questions about the nephrotoxic effects of analgesics remain unsolved.The clinical syndrome is well-defined, and clinicians from many parts of the world would agree that the clearcut syndrome documented in the paper by Gault, Rudwal, Engles, and Dossetor (3) beginning on p. 906 of this issue can be recognized without...References1. SPÜHLERZOLLINGER OHU: Die chronische interstitielle nephritis. Z. Klin. Med. 151: 1, 1953. MedlineGoogle Scholar2. Phenacetinabusus und Nierenschädigung. Georg Thieme Verlag, Stuttgart, 1958. Google Scholar3. GAULTRUDWALENGLESDOSSETOR MHTCWDJB: Syndrome associated with the abuse of analgesics. Ann. Intern. Med. 68: 906, 1968. LinkGoogle Scholar4. DAWBORNFAIRLEYKINCAID-SMITHKING JKKFPWE: The association of peptic ulceration, chronic renal disease and analgesic abuse. Quart. J. Med. 35: 69, 1966. MedlineGoogle Scholar5. SCHREINER GE: The nephrotoxicity of analgesic abuse. Ann. Intern. Med. 57: 1047, 1962. LinkGoogle Scholar6. PLASS HF: Renal papillary necrosis associated with analgesic abuse. Ann. Intern. Med. 60: 111, 1964. LinkGoogle Scholar7. ARNOLD JW: Reversible renal shutdown secondary to necrotizing renal papillitis. Report of a case. Northwest Med. 63: 168, 1964. MedlineGoogle Scholar8. YOUNGHAYDONGRAYHECKERLEE JVGBCPSPPR: Nephropathy associated with the use of analgesic medications. Ann. Intern. Med. 62: 727, 1965. LinkGoogle Scholar9. HARROW BR: Renal papillary necrosis. A critique of pathogenesis. J. Urol. 97: 203, 1967. CrossrefMedlineGoogle Scholar10. SØRENSEN AW: Is the relationship between analgesics and renal disease coincidental not causal? Nephron 3: 366, 1966. CrossrefMedlineGoogle Scholar11. CLAUSEN E: Renal damage following long term administration of phenacetin and acetylsalicylic acid. Munksgaard, Copenhagen, 1967. Google Scholar12. FELLERSPRADILLACRAIG FXAJM: The enhancement of salicylate toxicity by diamox, in Progress in Pyelonephritis, edited by KASS, E. H., F. A. Davis Co., Philadelphia, 1965, p. 337. Google Scholar13. FORDHAMHUFFINESWELT CCWDLG: Phenacetin-induced renal lesions in the rat, Ibid., p. 325. Google Scholar14. ABRAHAMSLEVIN CNW: Experimentally induced analgesic nephropathy. Med. Proc. 13: 506, 1967. Google Scholar15. KINCAID-SMITHSAKERMCKENZIE PBMIF: Lesions in the blood supply of the papilla in experimental analgesic nephropathy. Med. J. Aust. 1: 203, 1968. CrossrefMedlineGoogle Scholar16. GILMAN A: Pharmacologic problems in evaluation of the role of analgesics in production of renal disease, in Progress in Pyelonephritis, edited by KASS, E. H., F. A. Davis Co., Philadelphia, 1965, p. 353. Google Scholar17. KINCAID-SMITH P: Pathogenesis of the renal lesion associated with the abuse of analgesics. Lancet 1: 859, 1967. CrossrefMedlineGoogle Scholar18. SANNERKIN NG: Chronic phenacetin nephropathy. Brit. J. Urol. 38: 361, 1966. CrossrefMedlineGoogle Scholar19. BURRYDEJERSEYWEEDON AFPD: Phenacetin and renal papillary necrosis. Results of a prospective autopsy investigation. Med. J. Aust. 1: 873, 1966. CrossrefGoogle Scholar20. BLUEMLEGOLDBERG LWM: Mechanism of papillary necrosis in nephropathy of analgesic abuse (abstract). Clin. Res. 15: 351, 1967. Google Scholar21. KINCAID-SMITH P: Renal papillary necrosis and analgesic abuse. Postgrad. Med. J. In press, 1968. CrossrefGoogle Scholar22. BURRY AF: A profile of renal disease in Queensland. Results of an autopsy survey. Med. J. Aust. 1: 826, 1966. CrossrefMedlineGoogle Scholar23. LJUNGQVISTRICHARDSON AJ: Studies on the pathogenesis of serum induced renal papillary necrosis in the rat. Lab. Invest. 15: 1395, 1966. MedlineGoogle Scholar24. KINCAID-SMITH P: Analgesic nephropathy in perspective. Med. J. Aust. 2: 320, 1967. CrossrefMedlineGoogle Scholar25. KRIKLER DM: Paracetamol and the kidney. Brit. Med. J. 1: 615, 1967. CrossrefGoogle Scholar26. DUBACHLEVYMINDER UCPSF: Epidemiological study of analgesic intake and its relationship to urinary tract disorders in Switzerland. In press, 1968. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Renal Unit Royal Melbourne Hospital Melbourne, Victoria Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCaffeine potentiation of mefenamic acid-induced lesions in the rat renal medullaTransitional cell tumors of the renal pelvis and ureter associated with capillarosclerosis indicating analgesic abuseAnalgesic-associated nephropathyCharacterization of renal tissue lymphocytes in patients with interstitial nephritisAnalgesic nephropathy in Canada: Clinical syndrome, management, and outcomeAcute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitisCAFFEINE IN AMERICA'S FOOD AND DRUG HABITSMedullary Ischaemia in Experimental Analgesic Nephropathy-The Pathogenesis of Renal Papillary Necrosis*SURVEY OF ANALGESIC CONSUMPTIONCHLORAMPHENICOL OVER THE COUNTERANALGESIC ABUSE IN PSYCHIATRIC PATIENTSCase 7-1970More Notes on Recent ANNALS ThemesE. J. H.Analgesic nephrotoxicity 1 April 1968Volume 68, Issue 4Page: 949-952KeywordsAnalgesicsKidneys ePublished: 1 December 2008 Issue Published: 1 April 1968 PDF downloadLoading ...