Key result
Combination chemotherapy and hormone replacement led to complete regression of diffuse large B-cell lymphoma in the adrenal glands and thyroid, though the patient died of pneumonia at 8 months.
Case Report (n=1)
This case highlights an extremely rare presentation of diffuse large B-cell lymphoma involving both the adrenal glands and thyroid, leading to adrenal failure and hypothyroidism.
Suggests combined therapy feasibility in rare adrenal-thyroid DLBCL; leaves open optimal infection prophylaxis and survival impact.
A 55-year-old male presented with an initial manifestation of primary adrenal insufficiency, hypothyroidism. Computed tomography scans showed enlarged bilateral adrenal glands and thyroid. A pathological diagnosis of diffuse large cell, B cell lymphoma was made by a needle biopsy of the adrenal gland. He was treated with combination chemotherapy and adrenal and thyroid hormone replacement. The lymphoma subsequently involved the central nervous system. He died of pneumonia 8 months after the presentation of the first symptom. The postmortem examination demonstrated a complete regression of lymphoma in the bilateral adrenal glands and thyroid. This is an extremely rare case of coexistent lymphoma of the adrenal glands and the thyroid presenting with adrenal failure and hypothyroidism.
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Nasu et al. (1998) conducted a case report in Non-Hodgkin's lymphoma with adrenal insufficiency and hypothyroidism (n=1). Combination chemotherapy and hormone replacement was evaluated on Clinical course and autopsy findings. Combination chemotherapy and hormone replacement led to complete regression of diffuse large B-cell lymphoma in the adrenal glands and thyroid, though the patient died of pneumonia at 8 months.
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