Why the study?
Bilateral adrenal masses presenting as diffuse large B-cell lymphoma is a rare oncologic diagnosis requiring expedited work-up and treatment.
Case Report (n=1)
This case highlights a rare presentation of diffuse large B-cell lymphoma as bilateral adrenal masses causing adrenal insufficiency.
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Bilateral adrenal masses may signal lymphoma in adrenal insufficiency; hypothesis-generating for biopsy and management protocols.
We describe the case of a 50-year-old man who presented with a 2-month history of nausea, emesis, right lower quadrant pain and a 11-kg weight loss. Computed tomography of the abdomen unexpectedly revealed bilateral adrenal masses. Laboratory studies revealed adrenal insufficiency and hypercalcemia. After ruling out pheochromocytoma, adrenal biopsy identified diffuse large B-cell lymphoma. He was treated with hydrocortisone, fludrocortisone, and a chemotherapy regimen of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone before discharge. This report contributes a presentation of a rare oncologic diagnosis, the importance of expedited work-up, and a discussion of currently indicated treatments.
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Oommen et al. (2026) conducted a case report in Diffuse large B-cell lymphoma presenting as bilateral adrenal masses (n=1). Hydrocortisone, fludrocortisone, and chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) was evaluated.
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