The Effects of Halothane on Pressor and Depressor Responses Elicited via the Somatosympathetic Reflex

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Population

Rats anesthetized with α-chloralose (50 mg/kg) and urethane (500 mg/kg) and mechanically ventilated.

Comparison

Halothane administered during electrical… vs Baseline controls and a separate control group…

Design

Preclinical

Authors

Discussion

Halothane attenuates reflexes in rats; hypothesis-generating for antinociception without clinical translation.

Population

Rats anesthetized with α-chloralose (50 mg/kg) and urethane (500 mg/kg) and mechanically ventilated.

Intervention

Halothane (0.25%, 0.5%, and 1.0%) administered during electrical stimulation of the tibial or sciatic nerve.

Comparator

Baseline controls (prior to halothane) and a separate control group receiving intravenous sodium nitroprusside (SNP).

Outcome

Changes in mean arterial pressure (MAP) and heart rate (HR) elicited by electrical stimulation of peripheral nerves.surrogate

Halothane inhibits both excitatory and inhibitory types of the somatosympathetic reflex in rats, supporting a potential antinociceptive action.

Samsó et al. (1994) studied this question.

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