Key result
Halothane inhibits cardiac sympathetic ganglia responses to nicotinic receptors via postsynaptic neurons in spinal dogs.
Why the study?
The effects of halothane on cardiac sympathetic ganglia responses to various stimulants were not fully understood.
Population
Spinal dogs
Comparison
Halothane at 1 and 1.5 per cent vs no halothane
Design
Preclinical experimental study
Authors
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Halothane's ganglionic effects in spinal dogs warrant no clinical change; leaves open postsynaptic mechanisms for human sympathetic research.
In a canine model, halothane specifically inhibits nicotinic ganglionic receptors in cardiac sympathetic ganglia via postsynaptic neurons.
Alper et al. (1969) studied this question. Halothane was evaluated on Heart rate as the index of ganglionic activation. Halothane specifically inhibited the response of cardiac sympathetic ganglia to nicotinic ganglionic receptors only, acting through an effect on the postsynaptic neuron in spinal dogs.
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