What question did this study set out to answer?

To determine whether inhibiting adipose tissue lipolysis reduces circulating plasma concentrations of cyclic AMP, free fatty acids, and total catecholamines.

January 12, 1976Acta Medica Scandinavica

The Effect of Antilipolytic Agents on Cyclic AMP, Free Fatty Acid and Total Catecholamine Concentrations in Plasma

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Why the study?

Does a nicotinic acid analogue decrease plasma cyclic AMP concentrations in patients with acute myocardial infarction and dogs infused with isoprenaline?

Population

15 patients with acute myocardial infarction and 6 dogs given infusions of isoprenaline

Design

Other

Authors

RSRichard C. StrangeEuropean Union MRMichael RoweUniversity of Lincoln OΜOle D. ΜjøsUiT The Arctic University of Norway

Discussion

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Implication

Antilipolytic agents should not be used to lower plasma cAMP in acute MI; leaves open the primary source of circulating cyclic AMP.

Key Points

To determine whether inhibiting adipose tissue lipolysis reduces circulating plasma concentrations of cyclic AMP, free fatty acids, and total catecholamines.
Measured plasma cyclic AMP and free fatty acid concentrations in 15 patients with acute myocardial infarction and 6 dogs receiving isoprenaline infusions.
Administered a nicotinic acid analogue to inhibit adipose tissue lipolysis and quantified plasma total catecholamines in the patient cohort.
Inhibition of adipose tissue lipolysis using a nicotinic acid analogue failed to decrease plasma cyclic AMP concentrations in patients with acute myocardial infarction.
Lipolysis inhibition similarly did not reduce elevated plasma cyclic AMP levels in isoprenaline-infused dogs, demonstrating that adipose tissue is not a major contributor to circulating cyclic AMP.

Structured PICO

Does a nicotinic acid analogue decrease plasma cyclic AMP concentrations in patients with acute myocardial infarction and dogs infused with isoprenaline?

Population

15 patients with acute myocardial infarction and 6 dogs given infusions of isoprenaline

Intervention

Nicotinic acid analogue (antilipolytic agent)

Outcome

Plasma concentrations of cyclic AMP, free fatty acids, and total catecholaminessurrogate

Adipose tissue is likely not a major source of plasma cyclic AMP, as antilipolytic agents do not decrease its concentration.

Cite This Study

Strange et al. (1976) studied this question.

synapsesocial.com/papers/6a901aec33cf5c591c0d39cc https://doi.org/10.1111/j.0954-6820.1976.tb06758.x

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The Effect of Antilipolytic Agents on Cyclic AMP, Free Fatty Acid and Total Catecholamine Concentrations in Plasma

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Effect of Antilipolytic Agents on Cyclic AMP, Free Fatty Acid and Total Catecholamine Concentrations in Plasma

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider