Why the study?
What is the dose-response relationship and time course of neuromuscular blockade of ORG-9426 in children during nitrous oxide-halothane anesthesia?
Population
74 children undergoing nitrous oxide-halothane anesthesia
Comparison
ORG-9426 bolus doses vs Different doses of ORG-9426
Design
RCT, patients randomly received initial bolus doses
Authors
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Provides dosing guidance for rapid intubation in children; extends adult neuromuscular blocker data to pediatrics under halothane anesthesia.
What is the dose-response relationship and time course of neuromuscular blockade of ORG-9426 in children during nitrous oxide-halothane anesthesia?
ORG-9426 provides rapid onset of neuromuscular blockade in children during nitrous oxide-halothane anesthesia, with an ED95 of 303 micrograms/kg.
Woelfel et al. (1992) studied this question.
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