Why the study?
What are the pharmacodynamic characteristics and dose requirements of ORG 9426 during isoflurane anesthesia in adults?
Population
72 adult patients under steady-state expired isoflurane concentration of approximately 1%
Design
Other
Authors
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Supports initial dosing for ORG 9426 under isoflurane; leaves open confirmation of onset, duration, and safety in larger trials.
What are the pharmacodynamic characteristics and dose requirements of ORG 9426 during isoflurane anesthesia in adults?
ORG 9426 demonstrates rapid onset and short duration of action as a nondepolarizing muscle relaxant during isoflurane anesthesia, with no apparent cardiovascular side effects.
Quill et al. (1991) studied this question.
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