Key result
Interleukin-10 receptor neutralization causes immune-mediated colitis in SJL mice, which is exacerbated by concurrent acute central nervous system viral infection.
Population
Four-week-old, female, specific pathogen free SJL/JCrHsd mice
Comparison
IL-10 receptor blocking antibody 250 μg… vs IgG1-specific isotype control with…
Design
Preclinical, assigned randomly to three experiments
Follow-up
up to 49 days post infection
Authors
Loading...
Highlights potential IL-10 pathway interactions in colitis during CNS infection; leaves open translation to human disease.
p-value: p=<0.05
IL-10R neutralization causes immune-mediated colitis in genetically predisposed mice, which is exacerbated by concurrent central nervous system-restricted viral infection.
Uhde et al. (2016) studied Theiler's murine encephalomyelitis and immune-mediated colitis. IL-10R blocking antibody vs. IgG1-specific isotype control was evaluated on Development of immune-mediated colitis and spinal cord inflammation (p=<0.05). Interleukin-10 receptor neutralization causes immune-mediated colitis in SJL mice, which is exacerbated by concurrent acute central nervous system viral infection.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: