Population
Saccharomyces cerevisiae cells
Comparison
Inducible expression of poliovirus 2Apro vs Expression of poliovirus 3Cpro
Design
Preclinical
Authors
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2Apro toxicity in yeast offers a cellular model for poliovirus protease effects; leaves open mammalian relevance and clinical translation.
Poliovirus 2Apro expression is highly toxic to yeast cells, causing growth arrest, morphological changes, and a profound block in RNA synthesis.
Barco et al. (1995) studied this question.
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