Key result
A tri-leaflet valve with a purge flow effectively washed out the sinus in in vitro models, reducing the potential for thrombus formation associated with flow separation.
Population
In vitro models of tri-leaflet valves for pulsatile heart-assist devices (12 models evaluated)
Comparison
Tri-leaflet valve design with a purge flow vs Different geometrical parameters of the valve
Design
Preclinical
Authors
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May guide valve engineering for mechanical support; hypothesis-generating for clinical thrombosis reduction pending in vivo data.
A novel tri-leaflet valve design with a purge flow improves sinus washout in vitro, potentially reducing thromboembolic complications in heart-assist devices.
Timmel et al. (2011) studied Thromboembolic complications in heart-assist devices (n=12). Tri-leaflet valve with a purge flow was evaluated on Sinus washout and residence time of blood. A tri-leaflet valve with a purge flow effectively washed out the sinus in in vitro models, reducing the potential for thrombus formation associated with flow separation.
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