The Responses of Thevenusheart to Catechol Amines and High Concentrations of 5‐hydroxytryptamine

The catechol amines excite the isolated heart of Venus mercenaria in a characteristic manner. This response was not obtained with phenethylamine, tyramine, ephedrine, or mescaline, nor with histamine, nor with the basic n-alkylamines. 5-Hydroxytryptamine had a distinctive effect at high concentrations (above 3x10(-6) M) different from that at lower doses. The response to high concentrations was dominated by an increase in muscle tone. Hearts exposed to high concentrations of 5-hydroxytryptamine and other tryptamine analogues for long periods became tachyphylactic to low doses of these substances. However, high doses of 5-hydroxytryptamine (about 2x10(-5) M) still excited the tachyphylactic heart, but the response was then like that to the catechol amines. When high bath temperatures rendered the heart insensitive to 5-hydroxytryptamine, high concentrations of this compound again had the catechol amine effect. The possibility of a physiological role for the catechol amines or high 5-hydroxytryptamine concentrations is discussed.