Key result
The ID+DD genotype of the ACE gene was significantly associated with gestational diabetes mellitus in Asian Indian pregnant women (p=0.0002).
Why the study?
Is the ACE gene insertion/deletion polymorphism associated with gestational diabetes mellitus in Asian Indian pregnant women?
Case-Control (n=200)
Is the ACE gene insertion/deletion polymorphism associated with gestational diabetes mellitus in Asian Indian pregnant women?
p-value: p=0.0002
The ACE gene insertion/deletion polymorphism (ID+DD genotype) is significantly associated with gestational diabetes mellitus in Asian Indian pregnant women.
May support GDM risk stratification in Asian Indians; leaves open prospective validation before clinical adoption.
INTRODUCTION: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first recognized during pregnancy. Insertion/deletion (I/D) polymorphism of a 287 bp Alu repetitive sequence in intron 16 of the angiotensin-converting enzyme (ACE) gene has been widely investigated in Asian Indian populations with different ethnic origins. The present study examined possible association between I/D polymorphism of the ACE gene and GDM in Asian Indian pregnant women. METHODS: A total of 200 pregnant women (100 GDM and 100 non-GDM) were recruited in this study and I/D polymorphism of a 287 bp Alu1 element inside intron 16 of the ACE gene was examined by polymerase chain reaction (PCR)-based gel electrophoresis. RESULT: The distribution of the variants like II, ID, and DD genotypes of ACE gene showed differences between normal GDM versus non-GDM subjects, and the frequency of the ID+ DD Vs II genotype was significant (p=0.0002) in the GDM group. CONCLUSION: ACE gene polymorphism was associated with GDM in Asian Indian pregnant women.
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Khan et al. (2013) conducted a case-control in Gestational diabetes mellitus (n=200). ACE gene I/D polymorphism (ID+DD genotype) vs. II genotype was evaluated on Frequency of the ID+DD vs II genotype in GDM vs non-GDM groups (p=0.0002). The ID+DD genotype of the ACE gene was significantly associated with gestational diabetes mellitus in Asian Indian pregnant women (p=0.0002).
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