Key result
Cognitive impairment affects up to 50% of older adults with chronic kidney disease, with no current guideline-specified treatments available to prevent or delay its progression.
Why the study?
Cognitive decline in older adults with CKD leads to severe complications, yet no guideline-specified treatments exist to prevent, delay, or treat it.
This review highlights the high prevalence of cognitive impairment in older adults with CKD and the lack of established treatments, pointing to exercise as a potential future intervention.
Highlights unmet need for cognitive interventions in older CKD patients; leaves open critical gaps for targeted prevention trials.
The care of older adults can be greatly complicated when an individual is diagnosed with chronic kidney disease (CKD). CKD is a common disease with an estimated worldwide prevalence of 11% to 13%. Cognitive impairment is found in older adult patients with all stages of CKD, with a prevalence as high as 50%. The mechanisms leading to cognitive impairment in patients with CKD are conjectured to be related to a combination of vascular, hormonal, inflammatory, and CKD-related toxic factors that influence brain structure and function. Cognitive decline in older adults with CKD can lead to devastating complications for patients and their caregivers. There are no medications or treatments specified in clinical guidelines to prevent, delay, or treat cognitive impairment in patients with CKD. Researchers are beginning to explore the potential of exercise and increased physical activity to improve cognitive function in older adults with CKD. This review provides an overview of cognitive decline in older adults with CKD, the clinical implications, and current treatment options.
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Hannan et al. (2019) conducted a review in Chronic kidney disease and cognitive impairment. Cognitive impairment affects up to 50% of older adults with chronic kidney disease, with no current guideline-specified treatments available to prevent or delay its progression.
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