Key result
A multimodal deep phenotyping approach during exercise distinguished distinct patterns of right ventricular-pulmonary arterial uncoupling among four subjects with different PH diagnoses.
Why the study?
Deep phenotyping of pulmonary hypertension with multimodal diagnostic exercise interventions can lead to early focused therapeutic interventions.
Does multimodality deep phenotyping during exercise distinguish mechanisms of RV:PA uncoupling in patients with suspected pulmonary hypertension?
Observational (n=4)
Does multimodality deep phenotyping during exercise distinguish mechanisms of RV:PA uncoupling in patients with suspected pulmonary hypertension?
Multimodality deep phenotyping during exercise provides novel insights into the mechanisms of RV:PA uncoupling in different subtypes of pulmonary hypertension.
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Hypothesis-generating for multimodal exercise phenotyping in suspected PH; prospective validation required before clinical adoption.
Raza et al. (2022) conducted an observational in Pulmonary hypertension (n=4). Multimodal diagnostic exercise interventions was evaluated on Right ventricular:pulmonary arterial (RV:PA) uncoupling, pulmonary impedance, and differential biventricular myocardial strain during exercise. A multimodal deep phenotyping approach during exercise distinguished distinct patterns of right ventricular-pulmonary arterial uncoupling among four subjects with different PH diagnoses.
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