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August 1, 1971Scandinavian Journal of Haematology

Inhibition of Thrombin‐Induced Aggregation of Human Platelets by Heparin and Antithrombin III

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Population

Washed human platelets

Comparison

Heparin and antithrombin III vs Antithrombin III alone

Design

Preclinical

Authors

CEC. EikaOslo University Hospital

Discussion

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Implication

No immediate clinical implications; leaves open whether antithrombin synergy improves human thrombotic outcomes.

Structured PICO

P
Population
Washed human platelets
I
Intervention
Heparin and antithrombin III
C
Comparator
Antithrombin III alone
O
Outcome
Thrombin-induced platelet aggregation and release of platelet adenine nucleotidessurrogate

Heparin and antithrombin III synergistically inhibit thrombin-induced human platelet aggregation and nucleotide release in vitro.

Cite This Study

C. Eika (1971) studied this question.

synapsesocial.com/papers/6a9039d36bfd95d7bd4dd1e9https://doi.org/10.1111/j.1600-0609.1971.tb00872.x

Topics

Sermorelin
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Adenosine Derivatives and Antihistaminics on Platelet Aggregation1966 · 31 citations
  2. 2Inhibition of the Thrombin‐Fibrinogen Reaction by Heparin and Purified Cofactor1968 · 69 citations
  3. 3The antithrombin activity of heparin1954 · 62 citations