Why the study?
Does high-dose endotoxin directly activate the fibrinolytic system in vitro?
Population
In vitro model using normal human plasma (n=5) and factor XII deficient plasma
Comparison
High-dose endotoxin (E. coli 0128:B12, >0.1 mg/ml) vs Baseline/no endotoxin, and factor XII deficient…
Design
Preclinical
Authors
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High-dose endotoxin does not explain in vivo fibrinolysis; leaves open secondary mechanisms in clinical infections.
Does high-dose endotoxin directly activate the fibrinolytic system in vitro?
High-dose endotoxin directly activates the contact system and enhances plasminogen activator activity in vitro, but the required dose is too high to explain in vivo fibrinolysis, suggesting secondary mechanisms are responsible in clinical infections.
Nouzuka et al. (1980) studied this question.
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