Key result
Changes in Ca2+ handling and likely slowing of crossbridge cycling rate play an important role in the onset of mechanical alternans in pressure-overload hypertrophy.
Population
Right ventricular papillary muscles from pressure-overload (POL) cardiac hypertrophy models
Design
Preclinical
Authors
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Caution against clinical extrapolation from rodent data; leaves open mechanistic role of Ca2+ handling in human hypertrophy.
Changes in calcium handling and likely slowing of crossbridge cycling rate contribute to the onset of mechanical alternans in pressure-overload cardiac hypertrophy.
Kotsanas et al. (1996) studied Pressure-overload cardiac hypertrophy. 5 microM ryanodine was evaluated on Force and intracellular Ca2+ transients. Changes in Ca2+ handling and likely slowing of crossbridge cycling rate play an important role in the onset of mechanical alternans in pressure-overload hypertrophy.
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