July 22, 2008Circulation
Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca 2+ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion
Key result
SERCA2a overexpression significantly reduced the number of episodes of ventricular tachycardia after ischemia-reperfusion in a porcine model.
Why the study?
Does SERCA2a overexpression reduce ventricular arrhythmias in a porcine model of ischemia-reperfusion?
Population
Porcine model of myocardial ischemia-reperfusion and permanent coronary artery occlusion
Comparison
Sarcoplasmic reticulum Ca2+ ATPase pump… vs Control group without SERCA2a overexpression
Design
Preclinical
Follow-up
24 hours
Authors
Discussion
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Implication
Should not change clinical practice; hypothesis-generating for SERCA2a modulation in postischemic arrhythmias.
Structured PICO
Does SERCA2a overexpression reduce ventricular arrhythmias in a porcine model of ischemia-reperfusion?
P
Population
Porcine model of ischemia-reperfusion and permanent coronary artery occlusion evaluating the effect of SERCA2a overexpression on ventricular arrhythmias.
I
Intervention
Sarcoplasmic reticulum Ca2+ ATPase pump (SERCA2a) overexpression via intracoronary gene delivery of adenovirus in the 3 main coronary arteries
C
Comparator
Control group without SERCA2a overexpression (implied by comparative statistics)
O
Outcome
Occurrence of ventricular arrhythmias (episodes of ventricular tachycardia and ventricular fibrillation) assessed by 24-hour ECG Holter recordingssurrogate
SERCA2a overexpression reduces ventricular arrhythmias after ischemia-reperfusion in a porcine model, suggesting that modulating postischemic Ca2+ overload may be a promising antiarrhythmic strategy.
Cite This Study
Prunier et al. (2008) studied Ventricular arrhythmias and myocardial ischemia. SERCA2a overexpression via intracoronary gene delivery of adenovirus vs. Control (no SERCA2a overexpression) was evaluated on Number of episodes of ventricular tachycardia. SERCA2a overexpression significantly reduced the number of episodes of ventricular tachycardia after ischemia-reperfusion in a porcine model.