Key result
Maternal immunization with the KE-9 live-vaccine strain resulted in viral RNA detection in calf skin samples without viremia or infectious virus excretion, indicating no persistent infection.
Observational (n=7)
Detection of live-vaccine viruses in skin biopsies of calves from vaccinated mothers does not indicate classical persistent infection and mainly represents a diagnostic issue.
No takes yet. Share an insight, caveat, or question.
Vaccine strain detection in calves warrants caution with live BVDV vaccines; leaves open transmission risks in eradication programs.
Wernike et al. (2018) conducted an observational in Bovine viral diarrhea virus (BVDV) infection (n=7). Maternal immunization with Npro and Erns double mutant BVDV-1 live-vaccine strain KE-9 was evaluated on Induction of classical persistent infection (viremia and virus shedding). Maternal immunization with the KE-9 live-vaccine strain resulted in viral RNA detection in calf skin samples without viremia or infectious virus excretion, indicating no persistent infection.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: