Key result
Breast cancer bone metastases in mice induced an eightfold overexpression of mouse-derived periostin in metastatic legs compared to noninoculated mice.
Why the study?
Does zoledronic acid affect periostin expression in nude mice with breast cancer bone metastases?
Population
Nude mice inoculated with human MDA-B02 breast cancer cells
Comparison
Zoledronic acid vs Vehicle
Design
Preclinical
Authors
Loading...
Supports periostin as stromal response marker in bone metastases; animal data leave open human validation and zoledronic acid effects.
Does zoledronic acid affect periostin expression in nude mice with breast cancer bone metastases?
Effect estimate: eightfold increase
Periostin is overexpressed by surrounding stromal cells in breast cancer bone metastases and could serve as a biochemical marker of the early stromal response.
Contié et al. (2010) studied Breast cancer bone metastases. Breast cancer bone metastases (MDA-B02 cells) vs. Noninoculated mice was evaluated on Periostin expression in metastatic legs (eightfold increase). Breast cancer bone metastases in mice induced an eightfold overexpression of mouse-derived periostin in metastatic legs compared to noninoculated mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: