Key result
A high fibrosis-4 index (≥2.67) was a significant predictor of the presence of coronary artery disease (OR 1.92; 95% CI 1.30-2.83; p=0.001) in patients undergoing computed tomography angiography.
Why the study?
Liver fibrosis scores have recently been linked to CAD, prompting investigation into the association between CAD and the fibrosis-4 index in patients undergoing CCTA.
Is the fibrosis-4 index (FIB-4I) associated with the presence of coronary artery disease in patients undergoing CCTA?
Cross-Sectional (n=1,244)
Is the fibrosis-4 index (FIB-4I) associated with the presence of coronary artery disease in patients undergoing CCTA?
The fibrosis-4 index (FIB-4I) may serve as a useful diagnostic indicator for the presence of coronary artery disease, particularly in hypertensive patients undergoing CCTA.
Liver fibrosis scores, indicative of hepatic scarring, have recently been linked to coronary artery disease (CAD). We investigated the association between CAD and the fibrosis-4 index (FIB-4I) in patients who underwent coronary computed tomography angiography (CCTA). This study included 1244 patients who were clinically suspected of having CAD. The presence or absence of CAD was the primary endpoint. FIB-4I was higher in the CAD group than in the non-CAD group (1.95 ± 1.21 versus [vs.] 1.65 ± 1.22, p < 0.001). FIB-4I was also higher in the hypertension (HTN) group than in the non-HTN group (1.90 ± 1.32 vs. 1.60 ± 0.98, p < 0.001). In all patients, high FIB-4I (≥2.67) was a predictor of presence of CAD (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.30–2.83, p = 0.001), and low FIB-4I (≤1.29) was proven to be a predictor of absence of CAD (OR: 0.65, 95% CI: 0.48–0.88, p = 0.006). In the HTN group, high and low FIB-4I levels, were found to be predictors for CAD (OR: 2.01, 95% CI: 1.26–3.21, p < 0.001 and OR: 0.65, 95% CI: 0.45–0.94, p < 0.022, respectively), in particular. FIB-4I may serve as a diagnostic indicator of the presence or absence of CAD in hypertensive patients undergoing CCTA.
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Hirata et al. (2023) conducted a cross-sectional in Coronary artery disease (n=1,244). High fibrosis-4 index (FIB-4I ≥2.67) vs. Low fibrosis-4 index was evaluated on Presence or absence of coronary artery disease (OR 1.92, 95% CI 1.30-2.83, p=0.001). A high fibrosis-4 index (≥2.67) was a significant predictor of the presence of coronary artery disease (OR 1.92; 95% CI 1.30-2.83; p=0.001) in patients undergoing computed tomography angiography.
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