What question did this study set out to answer?

To resolve conflicting models of human myelopoiesis by investigating whether myeloid lineages diverge through intermediary oligopotent progenitors or through direct unilineage commitment.

May 24, 2019Science Immunology

Identification of two distinct pathways of human myelopoiesis

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Authors

RDRoy DrissenJohn Radcliffe Hospital STSupat ThongjueaGerman Cancer Research Center KTKim Theilgaard‐MönchUniversity of Copenhagen

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Implication

Cellular analysis uncovers two distinct oligopotent progenitor pathways governing myelopoiesis in human cells, indicating a bifurcated model of blood cell lineage commitment.

Key Points

To resolve conflicting models of human myelopoiesis by investigating whether myeloid lineages diverge through intermediary oligopotent progenitors or through direct unilineage commitment.
Assessed human myeloid progenitor populations at single-cell resolution to map lineage potential and segregation patterns.
Evaluated differentiation trajectories across neutrophil, monocyte, lymphoid, mast cell, basophil, eosinophil, megakaryocyte, and erythroid fates.
Neutrophil and monocyte differentiation potential selectively cosegregated with the lymphoid lineage during early commitment.
Mast cell, basophil, and eosinophil potentials cosegregated with megakaryocyte and erythroid potential, colocalizing within restricted oligopotent single-cell progenitors.
Human myelopoiesis progresses along two distinct, complementary cellular pathways rather than directly into unilineage fates.

Cite This Study

Drissen et al. (2019) studied this question.

synapsesocial.com/papers/6a904b0c99ba4bd4fe89c91c https://doi.org/10.1126/sciimmunol.aau7148

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Implication

Cellular analysis uncovers two distinct oligopotent progenitor pathways governing myelopoiesis in human cells, indicating a bifurcated model of blood cell lineage commitment.

Identification of two distinct pathways of human myelopoiesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Identification of two distinct pathways of human myelopoiesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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