Population
Vascular smooth muscle strips isolated from the corpus cavernosum of impotent men
Comparison
Phenylephrine vs Younger patients compared to older patients
Design
Preclinical
Authors
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May support age-related corporal contractility changes in ED; hypothesis-generating from Level 5 data and requires prospective human confirmation.
Increased efficacy of phenylephrine-induced contractions in vitro suggests augmented corporal vascular smooth muscle contractility may contribute to impotence in older patients.
Christ et al. (1991) studied this question.
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