Key result
A single injection of enoxaparin resulted in a similar percentage of open dialyzer fibers compared to divided administration (91% vs 94%) during extended hemodialysis.
Why the study?
It was hypothesized that a single injection of low-molecular-weight heparin might sufficiently maintain dialyzer fiber patency during extended hemodialysis, and whether anti-Xa levels accurately predict fiber blocking remained uncertain.
Does a single injection of enoxaparin maintain dialyzer fiber patency as effectively as a divided dose in patients on extended nocturnal hemodialysis?
Population
20 stable patients on ENHD
Comparison
Single LMWH injection at dialysis start vs divided dose over two injections
Design
Random cross-over study
Follow-up
Two consecutive midweek sessions
Authors
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Single LMWH dose may suffice for ENHD patency; leaves open anti-Xa utility pending larger trials.
RCT (n=20)
Random cross-over
Does a single injection of enoxaparin maintain dialyzer fiber patency as effectively as a divided dose in patients on extended nocturnal hemodialysis?
Absolute Event Rate: 91% vs 94%
A single injection of enoxaparin is sufficient to maintain dialyzer fiber patency during extended nocturnal hemodialysis up to 8 hours, without the need for divided dosing.
Thielemans et al. (2023) conducted an RCT in Extended (nocturnal) hemodialysis (n=20). Low-molecular-weight heparin (enoxaparin) single injection vs. Divided over two injections was evaluated on Percentage of open fibers in the dialyzers. A single injection of enoxaparin resulted in a similar percentage of open dialyzer fibers compared to divided administration (91% vs 94%) during extended hemodialysis.
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