January 1, 2004Kidney & Blood Pressure Research

Safety and Efficacy of Single Bolus Anticoagulation with Enoxaparin for Chronic Hemodialysis. Results of an Open-Label Post-Certification Study

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Why the study?

Does single bolus anticoagulation with enoxaparin provide safe and effective anticoagulation in patients undergoing chronic hemodialysis?

Population

781 stable chronic hemodialysis patients from 79 German dialysis centers, plus a sub-cohort of 22 patients…

Comparison

Single bolus anticoagulation with enoxaparin… vs Continuous anticoagulation regimen; no…

Design

Cohort, open-label

Follow-up

32 weeks

Authors

RKReinhard KlingelJohannes Gutenberg University Mainz ASAndreas SchwartingJohannes Gutenberg University Mainz JLJohannes LotzBrigham and Women's Hospital

Discussion

Member takes

Implication

Supports single-bolus enoxaparin safety in hemodialysis; hypothesis-generating and requires randomized confirmation before practice change.

Structured PICO

Does single bolus anticoagulation with enoxaparin provide safe and effective anticoagulation in patients undergoing chronic hemodialysis?

Population

781 stable chronic hemodialysis patients from 79 German dialysis centers (mean age 62 years; 31% ESRD due to diabetes mellitus), plus a sub-cohort of 22 patients for molecular marker analysis.

Intervention

Single bolus anticoagulation with enoxaparin (median dose 70.1 IU/kg) during chronic hemodialysis for 32 weeks.

Comparator

Continuous anticoagulation regimen (evaluated only in the 22-patient sub-cohort); no comparator for the main safety/efficacy cohort.

Outcome

Safety (adverse events, severe adverse events) and efficacy (significant clotting problems) during hemodialysis treatments.safety

Single bolus enoxaparin at a median dose of 70 IU/kg is a safe and effective anticoagulation strategy for chronic hemodialysis.

Cite This Study

Klingel et al. (2004) studied this question.

synapsesocial.com/papers/6a90502fe02ba012352daffa https://doi.org/10.1159/000079866

Topics

Anticoagulation in AF

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Implication

Supports single-bolus enoxaparin safety in hemodialysis; hypothesis-generating and requires randomized confirmation before practice change.

Safety and Efficacy of Single Bolus Anticoagulation with Enoxaparin for Chronic Hemodialysis. Results of an Open-Label Post-Certification Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Safety and Efficacy of Single Bolus Anticoagulation with Enoxaparin for Chronic Hemodialysis. Results of an Open-Label Post-Certification Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider