Key result
Enoxaparin sodium at a dose of 0.25 mg/kg significantly decreased minor bleeding compared to standard heparin in hemodialysis patients (P=0.03).
Why the study?
Does enoxaparin sodium reduce minor bleeding and clotting compared to standard heparin in patients undergoing maintenance hemodialysis?
Population
41 patients requiring maintenance hemodialysis due to end-stage renal failure, mean age 65.18, 53% male…
Comparison
Enoxaparin sodium administered 5 minutes before… vs Standard heparin 50 U/kg intravenously into the…
Design
RCT, randomly assigned
Follow-up
24 weeks (two 12-week crossover phases)
Authors
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May support LMWH as heparin alternative in hemodialysis; leaves open need for larger outcome trials.
RCT (n=45)
randomized, crossover
Does enoxaparin sodium reduce minor bleeding and clotting compared to standard heparin in patients undergoing maintenance hemodialysis?
p-value: p=0.03
A single dose of enoxaparin (0.25 mg/kg) is an effective and safe alternative to standard heparin for anticoagulation during hemodialysis, with a favorable bleeding profile at the reduced dose.
Tabiban et al. (2017) conducted an RCT in end-stage renal failure requiring maintenance hemodialysis (n=45). Enoxaparin sodium vs. Standard heparin was evaluated on minor bleeding (p=0.03). Enoxaparin sodium at a dose of 0.25 mg/kg significantly decreased minor bleeding compared to standard heparin in hemodialysis patients (P=0.03).
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