Population
A549 cells and WI-38 human lung fibroblasts (wound migrating cells)
Comparison
Expression of chimeric nonmuscle myosin IIs vs Expression of wild-type nonmuscle myosin IIA and…
Design
Preclinical
Authors
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C-terminal tail dictates myosin IIA/IIB specificity in migrating cells; leaves open relevance to cardiovascular cytoskeletal dynamics.
The C-terminal region of the nonmuscle myosin II heavy chain is the predominant factor directing isoform-specific distribution in migrating cells by controlling isoform solubility.
Sandquist et al. (2008) studied this question.
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