Key result
Inhibition of rho-dependent kinase by Y-27632 prevented the posterior accumulation of myosin IIB and inhibited tail retraction in migrating endothelial cells.
In migrating endothelial cells, the posterior accumulation of myosin IIB is specifically regulated by rho-dependent kinase-mediated light-chain phosphorylation, which is necessary for tail retraction.
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Distinct myosin IIA/IIB localizations in migrating endothelial cells support isoform-specific roles; leaves open contributions to vascular repair in vivo.
John Kolega (2003) studied Endothelial cell migration. Y-27632 (rho-kinase inhibitor) vs. Control (untreated or ML-7 treated) was evaluated on Posterior accumulation of myosin IIB and tail retraction. Inhibition of rho-dependent kinase by Y-27632 prevented the posterior accumulation of myosin IIB and inhibited tail retraction in migrating endothelial cells.