What question did this study set out to answer?

To determine whether antioxidant vitamin therapy improves endothelial function and alters surrogate biomarkers of oxidative stress and inflammation in children with hyperlipidemia.

August 11, 2003CirculationOpen Access

Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia

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Why the study?

Does antioxidant vitamin therapy improve endothelial function and affect surrogate biomarkers for oxidative stress and inflammation in hyperlipidemic children?

Population

15 children with familial hypercholesterolemia (FH) or the phenotype of familial combined hyperlipidemia (FCH)

Comparison

Antioxidant vitamins C and E for 6 weeks and the… vs Placebo

Design

RCT, randomized, double-blind

Follow-up

6 months

Authors

MEMarguerite M. EnglerUniformed Services University of the Health Sciences MEMary B. EnglerAmerican Heart Association MMMary J. MalloyUniversity of California, San Francisco

Discussion

Member takes

Implication

Supports endothelial benefit of vitamins C/E in hyperlipidemic children; extends adult data but questions oxidative-stress mediation.

Key Points

To determine whether antioxidant vitamin therapy improves endothelial function and alters surrogate biomarkers of oxidative stress and inflammation in children with hyperlipidemia.
Randomized, double-blind, placebo-controlled trial of 15 children with familial hypercholesterolemia or familial combined hyperlipidemia phenotype.
Patients received antioxidant vitamins C (500 mg/d) and E (400 IU/d) for 6 weeks alongside the National Cholesterol Education Program Step II (NCEP-II) diet for 6 months.
Endothelium-dependent flow-mediated dilation (FMD) of the brachial artery and biomarkers of oxidative stress, inflammation, and nitric oxide inhibition were measured.
Antioxidant vitamin therapy significantly improved brachial artery flow-mediated dilation compared with baseline (P < 0.001).
Vitamin supplementation showed no significant effect on surrogate biomarkers of oxidative stress (oxidized LDL autoantibodies, F2-isoprostanes, 8-hydroxy-2'-deoxyguanosine), C-reactive protein, or asymmetric dimethylarginine levels.

Structured PICO

Does antioxidant vitamin therapy improve endothelial function and affect surrogate biomarkers for oxidative stress and inflammation in hyperlipidemic children?

Population

15 children with familial hypercholesterolemia (FH) or the phenotype of familial combined hyperlipidemia (FCH)

Intervention

Antioxidant vitamins C (500 mg/d) and E (400 IU/d) for 6 weeks and the National Cholesterol Education Program Step II (NCEP-II) diet for 6 months

Comparator

Placebo

Outcome

Endothelium-dependent flow-mediated dilation (FMD) of the brachial arterysurrogate

Antioxidant therapy with vitamins C and E improves endothelial function in children with hyperlipidemia, which may help retard the progression of atherosclerosis.

Cite This Study

Engler et al. (2003) studied this question.

synapsesocial.com/papers/6a905ca84aebf474cb341d5a https://doi.org/10.1161/01.cir.0000086345.09861.a0

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Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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