Why the study?
Does escitalopram improve lipid profiles and reduce atherosclerotic changes compared to atorvastatin in rats with diet-induced atherosclerosis?
Population
Rats with high fat diet-induced atherosclerosis
Comparison
Escitalopram administered for 6 weeks vs Atorvastatin administered for 6 weeks, and an…
Design
Preclinical
Follow-up
6 weeks
Authors
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May support escitalopram investigation in human atherosclerosis trials; leaves open any clinical role pending prospective data.
Does escitalopram improve lipid profiles and reduce atherosclerotic changes compared to atorvastatin in rats with diet-induced atherosclerosis?
Escitalopram demonstrated anti-atherosclerotic and lipid-lowering effects comparable to atorvastatin in a rat model of diet-induced atherosclerosis.
Unis et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: