Why the study?
Does antithrombin III modulate TNF-alpha and IL-1beta synthesis in vascular smooth muscle cells?
Does antithrombin III modulate TNF-alpha and IL-1beta synthesis in vascular smooth muscle cells?
Antithrombin III exhibits concentration-dependent, contradictory effects on proinflammatory cytokine synthesis in vascular smooth muscle cells, suggesting it is not strictly an anti-inflammatory modulator.
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AT III's concentration-dependent cytokine effects caution against assuming anti-inflammatory benefit; leaves open its net role in human vascular inflammation.
Totzke et al. (2001) studied this question.
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