Why the study?
Does human antithrombin supplementation reduce microvascular protein leakage and adherence of leukocytes to mesenteric venules in endotoxin-challenged rats?
Does human antithrombin supplementation reduce microvascular protein leakage and adherence of leukocytes to mesenteric venules in endotoxin-challenged rats?
This preclinical study aims to elucidate the anti-inflammatory mechanisms of antithrombin on microvascular permeability and leukocyte adherence during endotoxemia.
No takes yet. Share an insight, caveat, or question.
Antithrombin effects on microvascular leakage in septic rats should not inform human care; leaves open translational validation in clinical endotoxemia.
Leithäuser et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: