October 24, 2014Cardiovascular ResearchOpen Access

Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes

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Population

Krox20(-/-) mutant mice and diseased human aortic valves

Comparison

Loss of function of Krox20 (Egr-2) vs Wild-type/normal controls

Design

Preclinical

Authors

GOGaëlle OdelinInserm EFEmilie FaureInserm FKFrank KoberCardiac Imaging

Discussion

Member takes

Implication

Hypothesis-generating for Krox20 in aortic valve disease; human validation required before any clinical translation.

Structured PICO

Population

Krox20(-/-) mutant mice and diseased human aortic valves

Intervention

Loss of function of Krox20 (Egr-2)

Comparator

Wild-type/normal controls

Outcome

Valvular structure and function (hyperplasia, ECM volume, aortic insufficiency, collagen expression)surrogate

Krox20-mediated activation of fibrillar Col1a1 and Col3a1 genes is crucial for heart valve development and preventing postnatal degeneration of aortic valve leaflets.

Cite This Study

Odelin et al. (2014) studied this question.

synapsesocial.com/papers/6a9068e2e02ba012352db810 https://doi.org/10.1093/cvr/cvu233

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Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider