Why the study?
Does Sabin's technique of intraspinal injection reduce the incidence of paralysis and poliomyelitis lesions compared to the standard technique in monkeys inoculated with attenuated poliovirus?
Population
Cynomolgus monkeys weighing 1.4-1.8 kg for live virus experiments, and Rhesus monkeys weighing 1.5-2.5 kg…
Comparison
Intraspinal injection of attenuated Type 3… vs Intraspinal injection using the 'standard…
Design
Preclinical
Follow-up
21 days
Authors
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Sabin's method may underestimate neurovirulence in animal models; leaves open the preferred technique for poliovirus vaccine safety testing.
Does Sabin's technique of intraspinal injection reduce the incidence of paralysis and poliomyelitis lesions compared to the standard technique in monkeys inoculated with attenuated poliovirus?
Sabin's technique of intraspinal injection results in a less widespread distribution of inoculum and lower sensitivity for detecting neurovirulence of attenuated poliovirus compared to the standard technique.
Beswick et al. (1961) studied this question.
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