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December 1, 1993Diabetes

Relationship Between the Circadian Rhythms of Blood Pressure and Sympathovagal Balance in Diabetic Autonomic Neuropathy

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Population

25 diabetic patients with various degrees of cardiovascular reflex impairment, mean age 45.6 ± 13.6 years…

Comparison

24-h noninvasive monitoring of blood pressure… vs Control subjects

Design

Cross-sectional

Follow-up

24-h

Authors

VSVincenza SpalloneUniversity of Rome Tor VergataLRLuigi RicordiUniversity of Rome Tor VergataACA CalciatiUniversity of Rome Tor Vergata

Discussion

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Implication

Links nocturnal sympathetic predominance to nondipping BP in diabetes; hypothesis-generating for autonomic modulation as CV risk target.

Structured PICO

P
Population
25 diabetic patients with various degrees of cardiovascular reflex impairment, mean age 45.6 ± 13.6 years, mean diabetes duration 17.6 ± 9.1 years.
I
Intervention
24-h noninvasive monitoring of blood pressure and ECG with autoregressive power spectrum analysis of RR interval variability
C
Comparator
Control subjects
O
Outcome
Correlation between day-night change in low frequency:high frequency ratio and day-night change in blood pressuresurrogate

In diabetic patients, the loss of day-night blood pressure rhythm is associated with nocturnal sympathetic predominance, which may represent a cardiovascular risk factor.

Cite This Study

Spallone et al. (1993) studied this question.

synapsesocial.com/papers/6a9070563de278877b83fbdfhttps://doi.org/10.2337/diab.42.12.1745
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Twenty-Four-Hour Pattern of Blood Pressure and Spectral Analysis of Heart Rate Variability in Diabetic Patients with Various Degrees of Autonomic Neuropathy. Comparison to Standard Cardiovascular Tests1996 · 42 citations
  2. 2Impaired circadian modulation of sympathovagal activity in diabetes. A possible explanation for altered temporal onset of cardiovascular disease.1992 · 239 citations
  3. 3Loss of Nocturnal Decline in Blood Pressure in Diabetic Patients with Autonomic Neuropathy.1992 · 3 citations
  4. 4Circadian blood pressure variation in diabetic patients with autonomic neuropathy1993 · 56 citations
  5. 5Twenty‐four Hour Blood Pressure and Heart Rate Profiles of Diabetic Patients with Abnormal Cardiovascular Reflexes1991 · 36 citations