Why the study?
As long as oral poliovirus vaccine is used, the potential risk for the emergence of vaccine-related polioviruses remains.
This case highlights the potential risk of vaccine-related poliovirus infection even in immunocompetent children who have received multiple doses of oral poliovirus vaccine, emphasizing the need to shift to inactivated vaccines.
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Sabin-like poliovirus infection can occur despite multiple OPV doses; leaves open enterovirus interference and need for enhanced surveillance.
BACKGROUND: As long as oral poliovirus vaccine (OPV) is used, the potential risk for the emergence of vaccine-related polioviruses remains. CASE SUMMARY: We report a case of Sabin-like type 1 poliovirus infection in an immunocompetent 17-mo-old child after receiving four scheduled doses of OPV. Somehow, the four doses did not confer full protection, possibly because of interference created by other enteroviruses. CONCLUSION: The surveillance of vaccine-related polioviruses has important implications for improving health policies and vaccination strategies. Missed cases of vaccine-related poliovirus infection might pose a potential risk to global poliovirus eradication. Therefore, the global withdrawal of OPV and a shift to the inclusion of only inactivated poliovirus vaccine in the vaccination schedule is the main objective of the polio eradication program.
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Taherkhani et al. (2021) studied this question.
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