Why the study?
Does simultaneous injection of DVE/MA or itaconic-acrylic acid with foot-and-mouth disease vaccine improve survival to subsequent virus injections in infant mice?
Does simultaneous injection of DVE/MA or itaconic-acrylic acid with foot-and-mouth disease vaccine improve survival to subsequent virus injections in infant mice?
Simultaneous administration of carboxylic acid interferon inducers with foot-and-mouth disease vaccine enhances resistance to subsequent viral challenge in infant mice.
Simultaneous injection of divinyl ether-maleic amhydride (DVE/MA) or itaconic-acrylic acid and foot-and-mouth disease virus vaccine enhanced the survival of infant mice to subsequent injections of virus. This enhanced resistance was obtained even with doses of interferon inducers which, when administered alone, failed to protect the mice. There was some increase in serum-neutralizing antibody in mice 7 days after injection of DVE/MA and vaccine, as compared with mice given vaccine alone, but there was no clear connection between antibody level and amount of DVE/MA administered.
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Campbell et al. (1973) studied this question.
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