Why the study?
Does inactivated poliovirus vaccine maintain type 2 poliovirus-neutralizing antibodies at 2 years postimmunization in children?
Does inactivated poliovirus vaccine maintain type 2 poliovirus-neutralizing antibodies at 2 years postimmunization in children?
The unexpected increase in type 2 poliovirus immunity 2 years post-IPV suggests widespread infection by circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi.
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Post-IPV type 2 seroprevalence rise may signal cVDPV2 circulation; hypothesis-generating for immunity durability in endemic settings.
This was a follow-up study conducted in 2020 assessing changes in levels of type 2 poliovirus-neutralizing antibodies 2 years postimmunization in children who received inactivated poliovirus vaccine (IPV) in Karachi, Pakistan. Unexpectedly, the findings revealed an increase in seroprevalence of type 2 antibodies from 73.1% to 81.6% 1 year and 2 years after IPV, respectively. The increase in type 2 immunity could result from the intensive transmission of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi during the second year of IPV administration. This study suggests that the cVDPV2 outbreak detected in Pakistan infected large proportions of children in Karachi. Clinical Trials Registration . NCT03286803.
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Saleem et al. (2023) studied this question.
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