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August 1, 1991Circulation

Expression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3.

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Authors

YSYoshinori SekoJuntendo University YSYoichi ShinkaiPioneer (United States)HYHideo Yagita∥Brigham Young University

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Implication

Suggests perforin+ lymphocytes drive viral myocarditis injury; leaves open whether targeting them alters human disease.

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Key points are not available for this paper at this time.

Cite This Study

Seko et al. (1991) studied this question.

synapsesocial.com/papers/6a907532ccd91641af4dda07 https://doi.org/10.1161/01.cir.84.2.788

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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

1Expression of major histocompatibility complex class I antigen in murine ventricular myocytes infected with Coxsackievirus B3.1990 · 70 citations
2Involvement of natural killer cells in coxsackievirus B3-induced murine myocarditis.1986 · 121 citations
3Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity.1987 · 188 citations