Why the study?
Does living attenuated poliovirus vaccine given orally effectively immunize infants less than two or three months old?
Does living attenuated poliovirus vaccine given orally effectively immunize infants less than two or three months old?
Infants under two to three months of age may have reduced susceptibility to infection by oral living attenuated poliovirus vaccines compared to older infants.
Infants <3 months may respond poorly to oral polio vaccine; leaves open optimal early immunization timing and strategies.
LIVING poliovirus was adapted for use as an immunizing agent a decade ago1; since then there have been an increasing number of studies to determine the action and the most efficacious use of attenuated poliovirus, especially in infants. It was first shown in 1956 that infants can be actively immunized with living attenuated poliovirus vaccine given orally, even while they still have passively acquired maternal poliomyelitis antibodies; these observations were subsequently confirmed.2 3 4 5 However, after it was found that infants less than two or three months old do not seem to be as readily infected with attenuated poliovirus as older . . .
No takes yet. Share an insight, caveat, or question.
Pagano et al. (1961) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: