March 1, 1985Journal of General Virology

Lack of Quantitative Correlation between the Neutralization of Poliovirus and the Antibody-mediated pI Shift of the Virions

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Population

Type 1 poliovirus

Design

Preclinical

Authors

PBPaul BrioenUniversité Officielle de Bukavu ATA A ThomasSalisbury University ABAlbert BoeyéVrije Universiteit Brussel

Discussion

Member takes

Implication

Questions role of pI shift in poliovirus neutralization; leaves open mechanistic requirements for antibody-mediated inactivation.

Structured PICO

Population

Type 1 poliovirus

Intervention

Mono- and polyclonal antibodies

Outcome

Infectivity and pI (isoelectric pH) of type 1 poliovirussurrogate

The study challenges Mandel's hypothesis by demonstrating a lack of quantitative correlation between poliovirus neutralization and antibody-mediated pI shift.

Cite This Study

Brioen et al. (1985) studied this question.

synapsesocial.com/papers/6a9079b9fdaee66aea840f6d https://doi.org/10.1099/0022-1317-66-3-609

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Lack of Quantitative Correlation between the Neutralization of Poliovirus and the Antibody-mediated pI Shift of the Virions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lack of Quantitative Correlation between the Neutralization of Poliovirus and the Antibody-mediated pI Shift of the Virions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider