Why the study?
Quinidine shifts between linear and non-linear pharmacokinetics and risks QT-elongation, necessitating an overview of available pharmacokinetic models and parameters.
Accurate pharmacokinetic modeling of quinidine is necessary to manage its narrow therapeutic index and dose-dependent QT prolongation.
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Supports TDM for quinidine amid nonlinear kinetics and QT risk; review leaves optimal ADME parameters open for validation.
This article takes you through the possible pharmacokinetic models and parameters for the antiarrhythmic drug Quinidine. The shuffle between the linear and non-linear pharmacokinetics of quinidine make it a candidate for therapeutic drug monitoring. The adverse effect in the form of QT-elongation is one of the major challenges to go for estimating good kinetics of the quinidine. The current article helps in providing a wide perspective towards the available models for the quinidine's ADME and compile the information published by several authors to help you to understand the quinidine pharmacokinetic behaviour.
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Mohd Riyaz Beg (2020) studied this question.
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